Forever young and mediation: to mindset at the outset.



It is well known the decaying of the gray matter with age. A growing body of research suggests that meditation practices are associated with substantial psychological as well as physiological benefits. In searching for the biological mechanisms underlying the beneficial impact of meditation, studies have revealed practice-induced alterations of neurotransmitters, brain activity, and cognitive abilities (1).
When correlating global and local gray matter with age, it is detected negative correlations within both controls and meditators, suggesting a decline over time. However, the slopes of the regression lines were steeper and the correlation coefficients were stronger in controls than in meditators.
This particular quality of non-evaluative awareness can improve one’s physical and psychological health status, and therefore several approaches generally called “mindfulness-based interventions” (MBIs) have been developed and tested in the last 40 years (9), although only over the last three decades the mindfulness meditation practices have been increasingly incorporated into psychotherapeutic programs, to take advantage of these benefits . Evidence about their efficacy and effectiveness in improving mindfulness and health is rapidly accumulating.

The role of meditation

The anatomy of the hippocampus has been repeatedly reported to differ between meditators and non-meditators. The human hippocampus shows structural differences between meditators and non-meditators as well as between men and women.
With the exact underlying neuronal mechanisms remaining to be established, studies linking meditation and brain structure are relatively sparse, but the hippocampus is consistently implicated as one of the structures altered in meditation practitioners (2).
Surprisingly, there are scanty published studies that have addressed the question of whether meditation diminishes age-related brain degeneration (4).
It has been suggested that this process is associated with a perceptual shift (12), in which one’s thoughts and feelings are recognized as events occurring in the broader field of awareness.

An underlying mechanism

Nothwithstanding, experiments using positron emission tomography or functional MRI (fMRI) within samples of novice or expert meditators indicated increased brain activation (compared to baseline) during meditation or mindfulness exercises in left and right hippocampal and parahippocampal regions (5)
When deeming the neural basis of the complex mental task of meditation, there are a lot of involved changes in cognition, sensory perception, affect, hormones, and autonomic activity (6)
Neuroimaging studies have begun to explore the neural mechanisms underlying mindfulness meditation practice with techniques such as EEG and functional MRI (12).

The hyppocampus: taken from

Group differences in the hippocampus and the right anterior insula, however, have each been identified in at least two of the studies. Furthermore, activation in both regions has been reported during meditative states, namely the hippocampus and the insula. The hippocampus is known to be critically involved in learning and memory processes, the modulation of emotional control, while the insula has been postulated to play a key role in the process of awareness, functions which have been shown to be important in the process and outcomes of mindfulness training (12).
Cross-sectional studies have established that differences in regional gray matter are associated with performance abilities (13, 14), suggesting that an increase in gray matter corresponds to improved functioning in the relevant area.

The insula. Taken from

What the evidence show

In the first study conducted by Eileen Luders et al, within a relatively large sample of meditators and well-matched controls, where global measures (hippocampal volumes) were complemented with refined local measures (radial hippocampal distances from surface to central core). After manually have labeled the hippocampus with a described procedure, the global left and right hippocampal volumes were established in mm3. Altogether, evaluated hyppocampal sizes were larger in meditators compared to controls, with up to 15% difference. ! These local effects were observed in several hippocampal regions in the left and right hemisphere though achieved significance primarily in the left hippocampal head (3).
Larger hippocampal dimensions in long-term meditators may constitute part of the underlying neurological substrate for cognitive skills, mental capacities, and/or personal traits associated with the practice of meditation (2).
In another exploratory single-group pilot longitudinal study it was examined the local gray matter changes over a six-week period of Mindfulness-based interventions (MBIs). The participants included six older adult community volunteers (M=66.5 years of age, SD=5.5, range=58-75; 66% female) with sleep disturbances. The Mindfulness-based interventions was delivered as a weekly, two-hour, six-session, group-based course in mindfulness meditation. Gray matter was measured voxel-wise pre- and post-intervention. It was found a significant gray matter increase identified within the precuneus, (posterior region of the medial parietal cortex, known to belong to the associative cortices, which is the widely distributed network sharing connections with other cortical and subcortical regions allowing the brain to integrate both external and self-generated information and to produce much of the mental activity that characterizes Homo sapiens sapiens) (10), possibly implicating meditation-induced changes of the default mode network. In contrast, observed significant gray matter decreases may have been driven by MBI-related remediation of brain architecture subserving sleep complaints (7).

right anterior insula and precuneus
(Left) right anterior insula and (Right) precuneus of brain. Taken from

Toward a mindfulness

The so called dispositional mindfulness (DM), is the tendency to be more mindful in daily life seems to be a sum of individual genetics and life experiences, and DM is not necessarily related to having participated in an mindfulness based intervention or practicing meditative exercises. DM can be measured by scales addressing mindfulness trait, e.g., the Mindful Attention Awareness Scale (MAAS) and the Five Facets Mindfulness Questionnaire (FFMQ) and it has been significantly related to several indicators of psychological and physical health including: higher levels of positive affect, improvement in personal stress management skills, and in adaptive emotional regulation (16).
The mindfulness may encourage self-regulation, may enhance values clarification, as well as cognitive, emotional and behavioral flexibility and tolerance for facing difficult emotional states. Increasing the objectivity through which internal experience is viewed is intended to change one’s relationship to the thoughts, as opposed to changing the thoughts themselves. For instance, the tendency to be more mindful in daily life has been associated with better psychological functioning and reduced overall distress in cancer patients. Being aware of the present moment and refraining from judging inner experience were the 2 most important mindfulness skills for improvements of psychological functioning among cancer patients (17).


The mindfulness based intervention

The psychological construct of mindfulness refers to an awareness that emerges by intentionally paying attention to the present experience in a non-judgmental way, as was described by Kabat-Zinn (15). In other words, a “mindful” mind brings together attentional and attitudinal features at the same time, self-regulating the attention toward present-moment, direct experiences and attitude in a non-judgmental tone toward internal and external phenomena (physical, affective and behavioral). Interest in mindfulness has increased exponentially in recent decades in academic and clinical contexts.
When approaching this mindfulness based intervention, a definition describes it as “paying attention in a particular way: on purpose, in the present moment, and non-judgmentally.” It has described mindfulness as a “way of being,” choosing to think of the work as a dynamic process, embedded within all of life, both intra- and inter-personal, rather than a static technique, practiced only “on the cushion” and thereby compartmentalized to “x” minutes per day (8)
This particular quality of awareness has been associated to several indicators of physical and psychological health, and can be developed using mindfulness-based interventions (MBIs), and therefore MBIs have been successfully applied as preventive and complementary interventions and therapies in medicine and psychology. Together with quiet sitting and lying meditation practices, mindful physical exercises such as “mindful walking” and “mindful movement” are key elements in MBIs and couple muscular activity with an internally directed focus, improving interoceptive attention to bodily sensations. In addition, MBIs seem to share similar mechanisms with physical fitness (PF) by which they may influence cardiovascular responses to stress (9).



A growing body of literature has demonstrated that neural systems are modifiable networks and changes in the neural structure can occur in adults as a result of training. These findings not only imply a close link between meditation and brain structure, but also suggest possible modulating effects of meditation on age-related brain atrophy. Given that normal aging is associated with significant loss of brain tissue, meditation-induced growth and/or preservation might manifest as a seemingly reducing brain age in meditators (i.e., cerebral measures characteristic of younger brains).
These results add to a growing literature depicts the impact of mindfulness and its relationship to improved psychological health. Moreover, specific mindfulness skills may be important in supporting these improvements, mainly taking into account the rising incidence and prevalence of brain atrophy conditions.


  1. Luders E, Cherbuin N, Kurth F. Forever Young(er): potential age-defying effects of long-term meditation on gray matter atrophy. Front Psychol. 2015 Jan 21;5:1551. doi: 10.3389/fpsyg.2014.01551. eCollection 2014.
  2. Luders E, Thompson PM, Kurth F. Larger hippocampal dimensions in meditation
    practitioners: differential effects in women and men. Front Psychol. 2015 Mar
    6;6:186. doi: 10.3389/fpsyg.2015.00186. eCollection 2015.
  3. Luders E, Thompson PM, Kurth F, Hong JY, Phillips OR, Wang Y, Gutman BA, Chou YY, Narr KL, Toga AW. Global and regional alterations of hippocampal anatomy in long-term meditation practitioners. Hum Brain Mapp. 2013 Dec;34(12):3369-75. doi: 10.1002/hbm.22153. Epub 2012 Jul 19.
  4. Luders E. Exploring age-related brain degeneration in meditation practitioners. Ann N Y Acad Sci. 2014 Jan;1307:82-8. doi: 10.1111/nyas.12217. Epub 2013 Aug 7.
  5. Engström M, Pihlsgård J, Lundberg P, Söderfeldt B. Functional magnetic resonance imaging of hippocampal activation during silent mantra meditation. J Altern Complement Med. 2010 Dec;16(12):1253-8. doi: 10.1089/acm.2009.0706.
  6. Newberg AB, Iversen J. The neural basis of the complex mental task of meditation: neurotransmitter and neurochemical considerations. Med Hypotheses. 2003 Aug;61(2):282-91.
  7. Kurth F, Luders E, Wu B, Black DS. Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxel-based Morphometry. Neuro. 2014;1(1):23-26.
  8. Cullen C: Mindfulness-Based Interventions: An Emerging PhenomenonMindfulness 2011; DOI 10.1007/s12671-011-0058-1
  9. Demarzo MMP, Montero-Marin J, Stein PK, Cebolla A, Provinciale JG, García-Campayo J. Mindfulness may both moderate and mediate the effect of physical fitness on cardiovascular responses to stress: a speculative hypothesisFrontiers in Physiology. 2014;5:105. doi:10.3389/fphys.2014.00105.
  10. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006 Mar;129(Pt 3):564-83.
  11. Hölzel BK, Carmody J, Vangel M, Congleton C, Yerramsetti SM, Gard T, Lazar SW. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30;191(1):36-43. doi: 10.1016/j.pscychresns.2010.08.006.
  12. Carmody J. Invited Commentary: Evolving Conceptions of Mindfulness in Clinical Settings. Journal of Cognitive Psychotherapy. 2009;23:270–280
  13. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biological Psychiatry. 2007;62:446–454.
  14. Mechelli A, Crinion JT, Noppeney U, O’Doherty J, Ashburner J, Frackowiak RS, Price CJ. Structural plasticity in the bilingual brain. Proficiency in a second language and age at acquisition affect grey-matter density. Nature. 2004;431:757
  15. Kabat-Zinn J. (2003). Mindfulness-based stress reduction (MBSR).Constr. Hum. Sci. 8, 73–107
  16. Garland S. N., Campbell T., Samuels C., Carlson L. E. (2013). Dispositional mindfulness, insomnia, sleep quality and dysfunctional sleep beliefs in post-treatment cancer patients. Pers. Indiv. Differ. 55, 306–311 10.1016/j.paid.2013.03.003
  17. Garland, S. N., Tamagawa, R., Todd, S. C., Speca, M., & Carlson, L. E. Increased mindfulness is related to improved stress and mood following participation in a mindfulness-based stress reduction program in individuals with cancer. Integrative Cancer Therapies, 2013; 12(1), 31–40.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s